Advances in the relation between myeloid derived suppre-ssor cells and digestive system tumors

Myeloid derived suppressor cell (MDSC) is a kind of myogenic stem cells that are induced by tumor-derived cytokines. MDSCs not only have their own immunosuppressive effects, but also can mediate the immunosuppressive effects of T lymphocytes through different mechanisms. Recent studies have shown that MDSCs involved in tumor immune escape, immune tolerance as well as other pathological processes, and played an important role in promoting the generation and development of tumors. The advances of the generation, immunosuppressive effects of MDSCs and their relation with digestive system tumors were summarized in this paper, which would provide evidences for the clinical use of MDSCs in treating digestive system tumors.