Explore the mechanism of bariatric surgery for metabolic syndrome from the“up-stream

Bariatric surgery can cure or alleviate metabolic syndrome, of which the mechanism is unclear, however. Several existing hypotheses including decreased caloric intake following the surgeries, foregut and hindgut hypothesis, serum bile acid and bacterial flora changes cannot completely explain the reasons of improvement of metabolic syndrome by various bariatric surgical procedures. Now the bariatric surgeries available are associated with stomach. The gastric center hypothesis is proposed in this article. There would be some particular cells in the gastric wall to secrete unknown hormones, which would be changed with decrease or deletion of stomach irritaion from food after bariatric surgeries, leading to remission of metabolic diseases. Focusing on the “upstream” stomach in the research on mechanism of bariatric surgery for metabolic syndrome, the fundamental cause of improvement of metabolic syndrome may be found out.