Expression and value of Formin 2 protein in colorectal cancer

Objective:To investigate the expression of Formin 2 protein ( FMN2) in the tissues of colorectal cancer (CRC) and relationship between clinicopathologic factors and prognosis of patients.
Methods:The clinicopathologic data of 335 patients with CRC who were admitted to the Xijing Hospital of Digestive Diseases from January 2008 to December 2011 were retrospectively analyzed. The colorectal specimens from surgical resection were analyzed. The expressions of FMN2 in the cancer and paracarcinoma tissues were examined by the immunohistochemistry. Patients were followed up through telephone interview and correspondence until June 2014. The comparison of rate and relationship between expressions of FMN2 and clinicopathologic factors were analyzed using the chisquare test. The survival curve was generated using the KaplanMeier method, and the survival analysis was conducted using the Logrank test.
Results:The expression of FMN2 was predominantly detected in the cytoplasm of the tumor cells. The positive rate of FMN2 protein expression in the CRC and paracarcinoma tissues were 53.73%(180/335) and 80.90%(271/335), respectively, with a significant difference (χ²=46.792, P<0.05). The expression level of FMN2 protein in patients with CRC was however associated with tumor differentiation, TNM stage and lymph node metastasis (χ²=7.707, 36.472, 40.635, P<0.05). A total of 322 patients were followed up for 3-36 months (median, 26 months) with a followup rate of 96.12%(322/335). The median survival time and 3year cumulative survival rate in 173 patients with negative expression of FMN2 protein were 30 months and 48.6%, which were compared with 36 months and 68.5% in 149 patients with positive expression of FMN2 protein, with a statically significance in the survival (χ²=16.283, P<0.05).
Conclusion:The low expression of FMN2 protein in the CRC is positively correlated with the occurrence and development of CRC, and it may be a prognostic indicator for patients.