Current status and reflection on radiotherapy in preoperative treatment of resectable gastric cancer

Radiotherapy has demonstrated certain efficacy in the treatment of gastric cancer. With the publication of a series of clinical studies, debates have arisen within the academic community regarding whether and how to apply radiotherapy in the preoperative treatment of gastric cancer. The authors elaborate on the anti-tumor biological mechanisms of radiotherapy, review the current research status of radiotherapy in preoperative treatment of resectable gastric cancer, and analyze existing challenges to explore future trends in neoadjuvant radiotherapy for gastric cancer and propose reflections on related issues. Through multidisciplinary integration and technological advance-ments, it is anticipated that the conceptual framework of radiotherapy for gastric cancer will evolve, achieving precision and individualization in radiotherapy to provide patients with more definitive survival benefits.