To do or not to do: surgical treatment for the non‑functional pancreatic neuroendocrine tumors

The incidence of pancreatic neuroendocrine tumors is increasing in recent years. Scientific treatment strategy will improve the prognosis of patients. Surgical resection is the main treatment for pancreatic neuroendocrine tumors, especially for localized tumors. At present, there are still controversies about the treatment of pancreatic neuroendocrine tumors at home and abroad. Based on the literature and clinical practice, the author combs the related controversies and suggests that the age, physical condition, tumor location, staging, grading and functional status of the patients should be taken into consideration when making the surgical plan. The individualized treatment of pancreatic neuroendocrine tumor should be realized according to the specific situation of the patients and the evidence‑based medicine.