Abstract: The pancreatico-enteric anastomisis has always been a great concern in pancreatoduodenectomy, even been called “Achilles heel”. Pancreatic surgeons are interested in improving the anastomosis technique to prevent the pancreatic fistula rate. More than a hundred of anastomosis techniques were reported, authors reviewed the history of pancreatico-enteric anastomisis and divided it into three historical stages, as well as summarized the characteristics of each stage. At the same time, auhors introduced the most representative anastomotic techniques and concepts in each period.