Objective To investigate the clinical value of fast track surgery (FTS) in donor in liver transplantation. Methods The clinical data of 214 donors for liver transplantation at the Renji Hospital of Shanghai Jiaotong University from January 2006 to November 2011 were retrospectively analyzed. All donors were divided into FTS group and conventional group. From January 2006 to May 2009, 73 donors who received conventional perioperative management were in the conventional group, and 141 donors who received FTS from May 2009 to November 2011 were in the FTS group. The recovery of the donors in the 2 groups was compared. All data were analyzed using the chi square test or t test. Results The operation time, time to out of bed activity, time to postoperative exsufflation, time to bowel movement, and duration of postoperative hospital stay were (178± 37)minutes, (1.6±1.0)days, (2.9±1.6)days, (3.1±1.5)days and (5.9±1.9)days in the FTS group, which were significantly shorter than (167±33)minutes, (3.6±1.4)days, (4.6±2.3)days, (4.5±1.4)days and (7.6±1.5)days in the conventional group ( t=2.115, 77.138, 6.504, 6.913, 6.970, P <0.05). The hospital costs of the FTS group and the conventional group were (1.8±0.6)×10 4 yuan and (2.2± 0.4) ×10 4 yuan, respectively, with a significant difference between the 2 groups ( t=73.038, P <0.05). The volumes of operative blood loss of the FTS group and the conventional group were (130±47)ml and (138± 46)ml, with no significant difference between the 2 groups ( t=1.251, P >0.05). The rate of satisfaction of the donors in the FTS group and conventional group were 98.6%(139/141) and 89.2%(74/83), respectively, with a significant difference between the 2 groups (χ 2=9.94, P <0.05). Conclusion FTS is safe, economical and can reduce stress, decrease hospital costs and promote early recovery of donors in liver transplantation.