Abstract: Laparoscopic surgery in hepatobiliary, splenic and pancreatic diseases is being widely used. However, the incidence of postoperative complications is relatively higher due to the complexity of the operative procedures. Surgeons are expected to have familiarity with normal and variant anatomy, as well as a good command of prevention and management of bleeding. Different separation techniques should be used based on the different characteristics of tissues. Moreover, digestive tract reconstruction is the technical bottleneck in laparoscopic hepatobiliary, splenic and pancreatic surgeries, and depending on the team work. Different anastomotic methods should be applied according to patients′ condition. Threedimensional laparoscopy and Da Vinci robot surgical system have greatly promoted the development of complex laparoscopic surgery in hepatobiliary, splenic and pancreatic surgeries. Comprehensive perioperative management and enhanced recovery after surgery are the guarantee of safe and quick postoperative recovery, which also fully embody the advantages of minimally invasive surgery.