Abstract: Hepatic failure is one of serious complications after hepatectomy. The individual′s preoperative physical health status, laboratory indicators, liver diseases, surgical factors, portal hypertension, and drug factors are all risk factors for hepatic failure. The author summarizes the risk factors for post hepatectomy liver failure(PHLF), analyzes the existing liver function scoring models, proposes the perioperative management strategy for patients undergoing hepatectomy according to the score index, so as to reduce the incidence of PHLF, improve the prognosis and long-term survival of patients.