肝细胞癌肝移植供肝选择策略

Selection of donor liver in liver transplantation for hepatocellular carcinoma

  • 摘要: 供肝数量不足是制约肝移植发展的主要因素,更是制约肝细胞癌肝移植治疗的突出因素。既往对肝细胞癌肝移植的研究多集中在受者选择标准、降期治疗、免疫抑制方案等方面,近年来研究发现供肝的选择对肝细胞癌肝移植术后肿瘤复发也有显著影响。笔者从临床供肝的主要类型、肝细胞癌肝移植适应证的把握、适应证内肝细胞癌肝移植和超适应证肝细胞癌肝移植的供肝选择以及供肝选择对肝细胞癌肝移植预后的影响进行深入探讨。

     

    Abstract: The shortage of donor liver is the main factor that restricts the development of liver transplantation and the curative effect of liver transplantation for hepatocellular carcinoma (HCC). Previous studies have focused on the selection criteria of recipient, downstaging therapy, immuno-suppressive therapy, etc. In recent years, it has been found that the selection of donor liver significantly inluence tumor recurrence after liver transplantation. The author discusses the main types of clinical liver donors, criteria of liver transplantation for HCC, selection of donor liver in liver transplantation for HCC within indications, selection of donor liver in liver transplantation for HCC beyond indications, and the influences of donor liver selection on the prognosis of liver transplantation for HCC.

     

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