Abstract: The new technique of single anastomosis duodenal-ileal bypass with sleeve gastrectomy appeared during recent years, which is a modification of biliopancreatic diversion with duodenal switch. The basic principles of this technique are restricted food intake by a sleeve gastrectomy and decreased absorption by the duodenal-ileal anastomosis. The new technique is relatively simple, with less malnutrition, better weight loss and metabolic disorders remission. The principle, surgical technique, results and possible complications are described, and the technique is also compared with existing weight loss operations in this article.