Abstract: Advances in surgical techniques have improved the precision and safety of liver surgery. However, there are still a large number of patients diagnosed unresectable at the first time and recurrence after liver surgery is universal. It is a tough challenge to prolong survival time of patients with advanced hepatocellular carcinoma (HCC). The authors′ center has made several attempts to improve 5-year survival of HCC patients. Enhanced recovery after surgery (ERAS) has been emphasized to improve surgical efficiency for patients with resectable HCC and multidisciplinary support has been emphasized to prolong survival time for unresectable HCC. Guideline for ERAS of Hepatectomy in West China Hospital of Sichuan University is conducted in the authors′ center aimed to shorten duration of hospital stay and strengthen interdisciplinary coordination after repeated clinical practice. Patients with advanced HCC can achieve survival benefits from recent breakthroughs in radiotherapy, molecular targeted therapy and immunotherapy. The authors in this article have introduced their clinical experience of ERAS in hepatic surgery, reviewed advances in multidisciplinary support and comprehensive treatment of HCC, discussed whole processing management of HCC.