Abstract: With the advent of a new era of digital medicine, the emergence of a series of digital intelligent diagnosis and treatment technology has played an important role in the development of diagnosis and treatment of biliary malignant tumors. In this paper, the application of digital intelligent technology in the diagnosis and treatment of biliary malignant tumors is elaborated based on the relevant literature at home and abroad as well as the author′s practical experience in the past 15 years. This paper introduces the application of digital medical technology represented by three-dimensional visuali-zation, virtual simulation surgery, three-dimension printing technology, virtual reality, abdominal surgery navigation, medical big data and artificial intelligence-radiomics in preoperative evaluation, operation planning, and real-time intraoperative guidance, and looks forward to the new direction of intelligent technology in the diagnosis and treatment of biliary malignant tumors, so as to promote its diagnosis and treatment mode to intelligent assisted diagnosis and treatment.