肝癌肝移植术后肿瘤复发的防治策略

樊嘉; 史颖弘; 田孟鑫

doi:10.3760/cma.j.issn.1673-9752.2019.01.004

肝癌肝移植术后肿瘤复发的防治策略

复旦大学附属中山医院肝外科，上海200032

基金项目: 国家自然科学基金重点项目(81530077)

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出版历程

Prevention and treatment strategies of postoperative tumor recurrence after liver transplantation for hepatocellular carcinoma

Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China

摘要

摘要:
肝移植是目前治疗肝癌最有效的方法，但是术后肿瘤复发严重影响其临床效果。当前精准医学和液体活组织检查等技术蓬勃发展，为肝癌肝移植患者诊断与治疗理念的更新提供了新思路。如何在“安全、有效、精准”的基础上，筛选肝移植术后肝癌复发相关的预后预测指标、完善肝移植患者选择的适应证、确定合理的术前局部治疗方案并制订肝癌复发后的干预措施，将有助于提高肝癌肝移植患者临床疗效并改善长期生存。
- 肝肿瘤 /
- 肝移植 /
- 复发 /
- 治疗
Abstract:
Liver transplantation is the most effective treatment for patients with hepatocellular carcinoma (HCC), however, postoperative tumor recurrence severely hampers its efficacy. With the development of precision medicine and liquid biopsy, the diagnosis and treatment of patients undergoing liver transplantation for liver cancer might be updated. On the basis of “safety, effectiveness and precision”, investigating the novel recurrence-related prognostic factors, improving the current indications of liver transplantation for patients with HCC, selecting optimal local regional treatments preoperatively and providing effective interventions for recurrent liver cancer after liver transplantation, may improve the long-term survival and therapeutic results of liver transplantation in patients with HCC.
- Liver neoplasms /
- Liver transplantation /
- Recurrence /
- Therapy