Abstract: Exocrine pancreatic insufficiency is a commom complication after pancreatic operation with high morbidity. At present, surgeons have insufficient understanding of it, and there is no internationally normalized standard for the diagnosis and treatment of exocrine pancreatic insufficiency.Through systematic reviewing of the relevant literature, this review summarizes the research progress of exocrine pancreatic insufficiency after pancreatic operation, including the definition of exocrine pancreatic insufficiency, aetiological agent, diagnosis, treatment, prevention, and morbidity of pancreatic exocrine insufficiency in different surgical procedures, in order to provide a reference for the improvement of diagnosis and treatment of exocrine pancreatic insufficiency in the future.