Abstract: Portal hypertension is a clinical syndrome of portal vein circulation disorder caused by multiple diseases. The assessment of portal vein pressure has important prognostic and clinical implications. However, there are great difficulties to carry out the hepatic venous pressure gradient. Recent non-invasive approaches to assess the portal vein pressure, including serum markers, ultrasonic testing, imaging and digital medical diagnosis technology has a steady progress. This article reviewed the recent approaches of the non-invasive assessment and the progress.