Abstract: Acute severe ulcerative colitis (ASUC) is a potentially life-threatening condition. Inappropriate salvage therapy might delay the surgery and increase the mortality and postopera tive complications in ulcerative colitis (UC). Timely surgical intervention for UC is the key to reduce the rate of mortality and postoperative complications via evaluating the effect of therapy combining with characters of patients′ history, clinical symptoms, biochemical markers, radiological and endoscopic criteria.