Abstract: The incidence of adenocarcinoma of the esophagogastric junction (AEG) has been raised in recently years. Comprehensive treatment based on surgical treatment is currently a general strategy for the treatment of AEG. As a minimally invasive treatment, laparoscopic surgery has been gradually applied to the treatment of AEG. Because of the particularity of the anatomy and pathology of AEG, laparoscopic radical resection still has many difficulties and controversies. Up to now, there are a few high-level evidences for the range of lymph node dissection and gastrectomy and the selection of digestive tract reconstruction,and the treatment strategy of total laparoscopic surgery for AEG has not reached a consensus. Therefore, laparoscopic surgery for AEG has gradually become a hot topic in clinical research. Here, combined with the experience of laparoscopic surgery for AEG and the latest guidelines and literatures, authors presented the general strategies for the laparoscopic treatment of AEG in our center.