Abstract: The world-wide incidence of adenocarcinoma of the esophagogastric junction has been on a rise in recent years. Surgical resection plays the most important role in the multimodal management for adenocarcinoma of esophagogastric junction. However, due to distinct anatomical position, biological features, epidemiology and surgical teams, many controversies and different cognitions exist among surgeons from the East and the West, including tumor staging and classification, regional lymphadenectomy, surgical approaches and extents of esophageal and gastric resection. A new TNM classification has renewed the staging system, while traditional Siewert classification still decides clinical surgical strategies. With the development of minimally invasive surgery and early detection for the lesion, it is possible to perform the operations combining laparoscopy and thoracoscopy in the future. A multidisciplinary team from digestive surgery, oncology, radiology and anesthesiology will be essential for optimal diagnosis and management.