Abstract: Pancreaticoduodenectomy (PD) is a standard surgical method for periampullary cancer. The hemorrhage is a dangerous complication after PD, how to effectively prevent and treat hemorrhage is a difficult point of pancreatic surgery, and also a key for reducing postoperative mortality. Four famous experts and their teams in surgical field explored prevention and treatment of the hemorrhage after PD from different angles based on clinical experiences. Professor Shen Boyong has conducted a discussion on early and late hemorrhage after PD combined with previous successful experiences and prospective research data. Professor Chen Yajin suggested preventing hemorrhage in the aspects of anatomical resection, anastomosis and reconstruction, peritoneal drainage-tube placement and postoperative management based on different causes of hemorrhage. Professor Peng Bing paid attention to hemorrhage after laparoscopic PD, and supposed that intraoperative careful hemostasis, precise anastomosis, reasonable peritoneal drainage-tube placement and optimal perioperative management can reduce incidences of postoperative pancreatic fistula, biliary fistula and intra-abdominal infection, thereby lowering the incidence of hemorrhage. Professor Tan Guang respectively proposed processing strategies of hemorrhage for grading A (mild at early stage), B (severe at early stage and mild at late stage) and C (severe at late stage).