微RNA-483与消化系统肿瘤关系的研究进展

Advances in the relationship between microRNA-483 and digestive system tumors

摘要: 微RNA(miRNA)是一种小分子的非编码单链RNA，通过翻译抑制或降解信使RNA在转录后水平调节基因表达。miRNA参与调节细胞的多种生物学过程，其表达水平的异常与肿瘤的发生密切相关。miR-483参与多种肿瘤的发生及演变，而其在消化系统肿瘤中的作用已引起广泛关注。

Abstract: MicroRNA （miRNA） is a kind of small noncoding RNA that regulates gene expression at the posttranscriptional level through inhibition of translation or degradation of messenger RNA. MiRNA is involved in the regulation of many cellular biological processes, and its abnormal expression closely relates to development of tumors. MiR-483 plays an important role in the tumorgenesis or development, meanwhile, its role in digestive system tumors has aroused widespread attention.