Abstract:
Objective:To compare the clinical effects between laparoscopic radical resection combined with radiofrequency ablation (RFA) and open radical resection for colorectal liver metastases.
Methods: The retrospective cohort study was conducted. The clinicopathological data of 120 colorectal liver metastases patients who were admitted to the Mengchao Hepatobiliary Hospital of Fujian Medical University (80 patients) and the Third Affiliated Hospital of Chongqing Medical University (40 patients) between September 2012 and April 2017 were collected. Sixty patients undergoing laparoscopic radical resection of colorectal cancer combined with RFA of liver metastases were allocated into the laparoscopy with RFA group, and 60 undergoing open radical resection of colorectal liver metastases were allocated into the open group. Observation indicators: (1) surgical and postoperative situations; (2) follow-up and survival situations. Follow-up using outpatient examination and telephone interview was performed to detect postoperative survival up to May 2017. Measurement data with normal distribution were represented as
±s, and comparisons between groups were analyzed using independent-sample t test. Measurement data with skewed distribution were described as M (range). Comparisons of count data were analyzed using chi-square test or Fisher exact probability. The repeated measures data were analyzed using the repeated measures ANOVA. The survival curve and rate were respectively drawn and calculated by the Kaplan-Meier method, and the Log-rank test was used for survival analysis.
Results:(1) Surgical and postoperative situations: ① All the patients underwent successful surgery, without conversion to open surgery in the laparoscopy with RFA group. Operation time, volume of intraoperative blood loss, cases with overall complications, death, abdominal pain, nausea and vomiting, liver dysfunction, pleural effusion, non-calculus cholecystitis and peptic ulcer and duration of postoperative hospital stay were respectively (135±34)minutes, (451±197)mL, 31, 0, 18, 6, 6, 4, 3, 2, (13±4)days in the laparoscopy with RFA group and (165±49)minutes, (794±204)mL, 42, 1, 15, 9, 10, 11, 5, 5, (19±4)days in the open group, with statistically significant differences in operation time, volume of intraoperative blood loss, cases with overall complications and duration of postoperative hospital stay between groups (t=3.983, 9.394, x
2=4.232, t=9.148, P<0.05), and no statistically significant differences in cases with death, abdominal pain, nausea and vomiting, liver dysfunction, pleural effusion, non-calculus cholecystitis and peptic ulcer between groups (x
2=0.376, 0.686, 1.154, 3.733, 0.134, 0.607, P>0.05). ② Levels of alanine aminotransferase (ALT), total bilirubin (TBil) and prothrombin time (PT) before operation, at day 1 and 3 postoperatively were respectively (70±9)U/L, (399±36)U/L, (231±19)U/L, (21±3)μmol/L, (26±3)μmol/L, (23±5)μmol/L, (17.3±2.4)seconds, (20.2±4.4)seconds, (18.9±2.8)seconds in the laparoscopy with RFA group and (68±8)U/L, (412±39)U/L, (253±22)U/L, (21±4)μmol/L, (28±4)μmol/L, (27±8)μmol/L, (16.6±3.0)seconds, (22.1±5.2)seconds, (20.1±4.4)seconds in the open group, with statistically significant differences in the levels of ALT, TBil and PT before operation, at day 1 and 3 postoperatively between groups (F=16.727, 13.115, 4.194, P<0.05). (2) Follow-up and survival situations: 120 patients were followed up for 7-24 months, with a median time of 20 months. The postoperative 1- and 2-year tumor-free survival rates, 1- and 2-year overall survival rates were respectively 23.3%, 11.9%, 85.0%, 40.0% in the laparoscopy with RFA group and 20.0%, 12.8%, 83.3%, 38.3% in the open group, with no statistically significant difference in above indicators between groups (x
2=0.145, 0.069, 0.012, 0.196, P>0.05). Further analysis showed that postoperative 2-year overall survival rate of patients with 1, 2, 3 and >3 liver metastasis lesions were respectively 53.3%, 38.2%, 40.0%, 16.7% in the laparoscopy with RFA group and 50.0%, 35.7%, 40.0%, 15.4% in the open group, with a statistically significant difference in 2-year survival rate of patients with different liver metastasis lesions in the laparoscopy with RFA group (x
2=20.949, P<0.05) and in the open group (x
2=21.349, P<0.05).
Conclusions:There are some advantages of fewer traumas, less complications, faster postoperative recovery and minimally invasive in laparoscopic radical resection combined with RFA for colorectal liver metastases, meanwhile, less liver metastasis lesions and better prognosis are found.
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