Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in China. It has high malignancy, strong invasion and metastasis, and a poor prognosis. It seriously threatens the life and health of people. With the development of modern medical technology, the treatment of HCC has developed into a comprehensive treatment mode based on surgical resection. At present, surgery is still the best cure for liver cancer. The treatment plan should be formulated according to different individuals, such as surgical treatment, ablation, embolization, chemotherapy, molecular targeted therapy, immunotherapy treatment and sequential application of that comprehensive treatment, to improve the overall efficacy of HCC and prolong the survival period and improve the quality of life of patients. The present situation of comprehensive treatment of HCC was discussed in this paper.