Abstract: Translational medicine is characterized by its close association with precision medicine in the field of colo-rectal cancer. In particular, the studies of life histology promote the prevention and treatment of colorectal cancer entered the stage of precision medicine. Accurate molecular typing of colo-rectal cancer has been used to guide clinical practice is an important breakthrough in the field of colorectal cancer translational medicine in recent years, and its clinical value has been verified. As an important tool for the effective integration of clinical data and life histology data, the biomedical big data platform is expected to contribute to the continued breakthrough of translational medicine in precision molecular typing. New treatment methods, such as liquid biopsy technology with non-invasive, flexible features can be dynamically detected as soon as possible to find the state of somatic mutations. Among them, circulating tumor DNA has a good detection sensitivity and specificity, highlighting the value of early recurrence monitoring. In addition, new therapeutic strategies, such as immunological checkpoints and chimeric antigen receptor genetically modified T-cell therapy, are under intense study in the field of colorectal cancer. Based on the biomedical big data analysis in the context of the precise molecular typing, dynamic liquid biopsy monitoring technology, new immunotherapy and other fields will be the future of colorectal cancer translational medicine research hot and breakthrough direction.