肝门部胆管癌术前行胆道引流术减轻黄疸的争议与策略

Controversy and strategy of preoperative biliary drainage reducing jaundice in hilar cholangiocarcinoma

  • 摘要: 根治性手术切除是肝门部胆管癌唯一可能治愈的手段,且多数患者需联合行肝切除术以达根治目的。多数肝门部胆管癌患者均合并不同程度的梗阻性黄疸。尽管行术前胆道引流术(PBD)可改善患者肝脏功能、凝血功能、营养状况、免疫功能,控制急性胆管炎,促进肝再生等,但其自身也有一系列弊端,导致其在肝门部胆管癌根治术中的应用价值目前仍存在较大争议。笔者结合文献资料和自身临床实践经验,围绕肝门部胆管癌行PBD的作用与弊端、应用价值、适应证及方式选择等内容做系统阐述,以期为临床实践提供参考。

     

    Abstract: The radical resection is the only curative way for hilar cholangiocarcinoma, and combined hepatectomy is usually needed to achieve the goal of radical resection. Most patients with hilar cholangiocarcinoma are accompanied by obstructive jaundice. Although preoperative biliary drainage (PBD) can improve liver function, blood coagulation function, nutritional status and immunologic function, control acute cholangitis and promote liver regeneration, but a series of its drawbacks currently lead to a big controversy about application value of radical resection of hilar cholangiocarcinoma. Through reviewing literatures and combining with clinical practice experiences, author suggested some ideas on effects, disadvantages, application value, indication and method selection of PBD that will provide a reference in clinical practices.

     

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