Abstract: Gallbladder cancer (GBC) is one of common cancers of the biliary tract. Surgery is the only possible way to cure this malignancy because other adjuvant therapies work ineffectively on GBC. This paper was aimed to discuss the hotspots and dilemmas in the field of surgery on GBC, such as preoperative jaundice, the role of tumor location on surgery, lymph node dissection, liver excision, combined vessel resection, the role of laparoscopy on surgery, and will provide clinical evidences for surgical treatment of GBC.