Abstract: The high standard diagnosis and treatment of pancreatic neoplasms demand multidisciplinary cooperation, especially in the treatment of local advanced and metastatic pancreatic cancer. For benign borderline tumors, multidisciplinary cooperation could improve the specificity of preoperative diagnosis so that unnecessary surgery could be avoided to greatest extend. Surgeons should balance the risk and gain of patients so that rational treatment could be achieved based on evidence medicine, and the long term survival could be accomplished.