Abstract: With the development of abdominal imaging examination, detection rate of pancreatic cystic neoplasms is increasing in recent years. Misdiagnosis and unreasonable treatment sometimes are unavoidable since the variable subtype, pathology and natural history. Multidisciplinary team (MDT) including surgeons, radiologists, gastro enterologists and patho logists is very helpful to make an exact diagnosis and appropriate treatment for pancreatic cystic neoplasms. However, because of the complexities of pancreatic cystic neoplasms, challenges and difficulties of MDT always exist. In this article, authors summarized the newest advancement of pancreatic cystic neoplasms and highlighted the experiences in the management of pancreatic cystic neoplasms from MDT, aiming to seek the optimal strategy.