Abstract: The 53^rd annual meeting of the American Society of Clinical Oncology (ASCO) was held in Chicago, United States between June 2 and 6, 2017. The latest advances in biliary tract cancer research from this meeting were summarized and analyzed in this paper. The adjuvant 〖HJ〗therapy in biliary tract cancer made a breakthrough in this meeting, the findings could provide the basis for a new standard of changing the current management model in the disease. The precision medicine and targeted therapy will be the development direction in the future. Doctors should attach great importance to the adjuvant and comprehensive therapy in biliary tract cancer and initiate high level multi-center clinical trials to improve the overall the diagnostic and treatment levels of biliary tract cancer.