Abstract: Precision medicine is a medical model that proposes the individual therapy, with a joint medical method of genomics, proteomics, metabolomics and clinical big data tailored to the individual patient. The diagnosis and treatment of colorectal cancer have entered the model of precision medicine with the entering the era of precision medicine. In this article, authors summarized the recent progress of diagnosis and therapy under the guidance of precision medicine, with an aim to provide some new clues for surgeons and supports for precision prevention, diagnosis and therapy.