Abstract: The incidence and mortality of colorectal cancer (CRC) increased rapidly in recent decades and become enormous challenges in China. Lack of effective early warning of molecular markers and dynamic monitoring technology in term of early diagnosis, treatment evaluation, dynamic recurrence and metastasis monitoring are the clinical diagnosis and treatment bottlenecks of CRC . Traditional diagnosis and treatment of CRC rely on a single level of patient information with low accuracy. Based on the system of biology medical model, to carry out a joint diagnostic model, will overcome the traditional problems through a number of multi level information integration of the joint diagnosis model, will significantly improve the sensitivity and specificity of diagnosis of CRC. The major challenge in patients with advanced and metastatic CRC is the instability of the tumor genome and the treatment induced resistance during chemotherapy and targeted therapy. It is necessary to carry out continuous dynamic biopsy in order to accurately guide the development of treatment decisions. Compared with the pathological examination of traditional surgical specimen, liquid biopsy, such as circulating tumor cells, circulating tumor DNA detection technology, with noninvasive, real time dynamic monitoring, could evaluate the efficacy of treatment, and guide the precise individual diagnosis and treatment. Today, the new strategy and new technology need to undergo clinical trials urgency, through technology optimization, reduction of costs and improvement of detection accuracy, would quickly extended to clinical applications in future.