450例腹腔镜Roux-en-Y胃旁路术后并发症的分析及处理

Causes analysis and management of postoperative complications after laparoscopic Roux-en-Y gastric bypass of 450 patients

  • 摘要: 目的:探讨腹腔镜RouxenY胃旁路术(LYRGB)后并发症的发生原因及其处理方法。
    方法:采用回顾性横断面研究方法。收集2004年6月至2016年11月暨南大学附属第一医院收治的283例(含58例会诊手术)、暨南大学附属暨华医院140例、暨南大学附属郑州医院27例行LRYGB代谢性疾病患者的临床资料。观察指标:患者手术完成情况、随访情况、并发症发生情况以及治疗和预后情况。采用门诊和电话方式进行随访。术后1年内第1、3、6、12个月各随访1次,术后1年后每年随访1次。随访内容为患者术后并发症情况。随访时间截至2017年3月。偏态分布的计量资料采用M(范围)表示。计数资料采用率表示,两者比较采用x2检验。
    结果:450例代谢性疾病患者均成功施行LRYGB,其中50例为医师学习曲线期间施行,400例为医师度过学习曲线后施行,均无中转开腹。450例患者均获得术后随访,中位随访时间为70个月(1~153个月)。术后27例患者发生并发症,并发症发生率为6.00%(27/450)。医师学习曲线期间施行LRYGB的50例患者,其并发症发生率为20.00%(10/50);医师度过学习曲线后施行LRYGB的400例患者,其并发症发生率为4.25%(17/400),两者比较,差异有统计学意义(x2=16.86,P<0.05)。27例发生并发症的患者中,暴发性胰腺炎1例于术后第 15天因多器官衰竭死亡,腹腔出血5例,吻合口漏2例,胃空肠吻合口狭窄3例,胃空肠吻合口溃疡2例,吻合错误1例,呼吸衰竭1例,脐孔感染 1例,内疝3例,倾倒综合征2例,减重失败6例(1例拒绝行修正手术)。上述发生并发症患者中,除1例死亡外,其余经手术或保守治疗后好转或治愈。
    结论:与开展LYRGB初期比较,医师度过学习曲线后LYRGB术后并发症发生率明显降低,术后并发症治疗方案需个体化制订。

     

    Abstract: Objective:To explore the causes and management of postoperative complications of laparoscopic RouxenY gastric bypass (LRYGB).
    Methods:The retrospective crosssectional study was conducted. The clinical data of 450 patients with metabolic diseases who underwent LRYGB between June 2004 and November 2016 were collected, including 283 (58 in hospital consultation) in the First Affiliated Hospital of Jinan University, 140 in the Jihua Hospital Affiliated to Jinan University and 27 in the Zhengzhou Hospital of Jinan University. Observation indicators: situations of surgical completion, followup situations, occurrence, treatment and prognosis of complications. Followup using outpatient examination and telephone interview was performed to detect postoperative complications once at month 1, 3, 6 and 12 within 1 year postoperatively and once every year after 1 year postoperatively up to March 2017. Measurement data with skewed distribution were described as M (range). Count data were evaluated by the ratio, and comparison between groups was analyzed using the chisquare test.
    Results: All the 450 patients with metabolic diseases underwent successful LRYGB, including 50 receiving LRYGB during surgical internship period and 400 receiving LRYGB after surgical internship period, without conversion to open surgery. All the 450 patients were followed up for 70 months (range, 1-153 months). Twentyseven patients had postoperative complications, with an incidence of 6.00%(27/450). The incidence of postoperative complications was 20.00%(10/50) in 50 patients receiving LRYGB during surgical internship period and 4.25%(17/400) in 400 patients receiving LRYGB after surgical internship period, with a statistically significant difference (x2= 16.86, P<0.05). Of 27 patients with postoperative complications, 1 was complicated with fulminant acute pancreatitis and died from multiple organ failure at day 15 postoperatively, 5 with intraabdominal bleeding, 2 with anastomotic leakage, 3 with gastrojejunal anastomosis stenosis, 2 with gastrojejunal anastomosis ulcer, 1 with improper anastomosis, 1 with respiratory failure, 1 with umbilicus infection, 3 with internal hernia, 2 with dumping syndrome, 6 with weightloss failure (1 refused to undergo revision surgery), and patients with postoperative complications were improved or cured by surgery or conservative treatment except one death.
    Conclusions:The incidence of complications in patients receiving LRYGB after surgical internship period is significantly reduced, and complications needs to make the individualized treatment plan.

     

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