Abstract: The definition, staging and optimal treatment of adenocarcinoma of esophagogastric junction (AEG) have long been in controversy. Surgery is still the primary treatment for resectable AEG, and surgical procedures depend on its classifications. However, the efficacy of surgery alone is barely satisfactory. Neoadjuvant chemoradiotherapy and perioperative chemotherapy can improve the survival of patients. Simplified “2 cm”principle is presented in the 8th edition of American Joint Committee on Cancer for TNM staging system of esophageal cancer. In addition, the new edition provides clinical staging and pathologic staging after neoadjuvant therapy, improving the clinical practicability of new staging system.