Abstract: Gallstone is a common and multiple benign disease, that has become an important public health problem. Focusing on the recent dispute about cholelithotomy or cholecystectomy and analysis of recent literatures, the author put forward to grasp the treatment principles performed by academician Huang Zhiqiang and discuss the crucial problems of treatment strategy about benign gallbladder disease from the following four aspects: (1) The key point of “Cholelithotomy” is to protect the gallbladder, not only to preserve the gallbladder. (2) The training, guidance and practice of clinical research on benign gallbladder diseases such as gallstones need to be further standardized. (3)The operation of gallstones is relatively easy while the and patients′ prognosis is relatively complex. The choice of surgical indications is very important, and both of over treatment and inadequate treatment should be emphasized. (4) The epidemiological investigation and prevention of gallstones need to be strengthened.