Abstract: The occurrence of malignant tumors is increasing annually around the world. In every year, 8.2 million patients died of malignant tumors in which about 90% patients died of malignant tumors associated multiple organs metastases. Inhibiting tumor metastasis is the key event to prolong the survi val time of patients. With the further research, tumor vessel associated extravascular tumor metastasis is playing an increasingly important role in the clinical application. This paper summarizes the new developments of tumor vessel associated extravascular tumor metastasis to provide possible ideas for the therapy of malignant tumors.