Ⅳ期胃癌的外科治疗

Surgical treatment of stage Ⅳ gastric cancer

  • 摘要: Ⅳ期胃癌是指具有非治愈因素的胃癌,患者长期生存率约为10%。不能切除的Ⅳ期胃癌其治疗方针以化疗为主,存在梗阻、出血等需行外科急诊姑息性手术。减量手术的临床价值已被相关研究否定。然而,仅存在1个非治愈因素(腹主动脉周围淋巴结转移、局限在第16a2和16b1组淋巴结肿大,腹膜转移程度为P0、腹腔内脱落癌细胞阳性,少数肝转移等),手术能达到R0或R1切除的Ⅳ期胃癌患者积极行包括外科切除的综合治疗具有良好的长期生存效果。因此,包含外科切除的综合治疗成为第一选择。近年来化疗转化治疗后行外科切除,改善Ⅳ期胃癌患者预后的研究也备受关注。

     

    Abstract: Stage Ⅳ gastric cancer is defined as gastric cancer with noncurative factors, and the longterm survival rate of patients with stage Ⅳ gastric cancer is around 10%. Chemotherapy has been used for the main therapy of the patients with unresectable stage Ⅳ gastric cancer. Palliative resection of the primary tumor has been recommended only for presence of obstruction, bleeding and other surgical emergency. Debulking operation was irrelevant to the outcome that has been considered by research results. However, the patients with stage Ⅳ gastric cancer of only one noncurative factors (No.16a2, b1 lymph node enlargement; degree of peritoneal metastasis as P0 and positive peritoneal cytology; a small number of liver metastases) have good longterm survival when these patients have achieved R0 or R1 resection. In this regard, comprehensive treatment including surgical resection is the main treatment policy for the patients with stage Ⅳ gastric cancer. In recent years, some clinical studies on improvement of prognosis through surgical resection after conversion therapy have received extensive attention.

     

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