Abstract: Hepatocellular carcinoma is one of the most common malignancies in the worldwide. Selected patients with hepatocellular carcinoma are candidates for curative resection, but nevertheless there is a high risk of tumor recurrence. Microvascular invasion (MVI) is an aggressive biological behavior and has repeatedly been identified as a risk factor for prognosis after curative treatment, meanwhile, it is now becoming increasingly concerned . It would be of great significance to distinguish MVI in an early stage and choose an appropriate treatment timely to get a definite improvement for the longterm survival in patients with hepatocellular carcinoma after curative treatment. This review focuses on some certain issues of MVI.