Abstract: Objective:To investigate the clinical efficacy of laparoscopic splenectomy combined with pericardial devascularization.
Methods:The retrospective cross-sectional descriptive study was adopted. The clinical data of 64 patients who underwent laparoscopic splenectomy combined with pericardial devascularization at the Second Affiliated Hospital of Kunming Medical University from April 2012 to June 2015 were collected. Observed indexes included (1) treatment outcomes, including surgical procedures, operation time, volume of intraoperative blood loss, time of postoperative enteral recovery, time of postoperative drainage tube removal, duration of postoperative hospital stay, occurrence of complications, (2)followup situation. The followup using reexaminations of blood routine, liver function, coagulation function, gastroscopy and color Doppler ultrasonography of portal vein was performed regularly at postoperative month 1, 2, 3, 6, 12, 24 until reemergence of gastrointestinal hemorrhage. The final deadline was death of patients and performance of liver transplantation. Measurement data with normal distribution were presented as ±s.
Results:(1) Treatment outcomes: of 64 patients, 62 underwent total laparoscopic splenectomy combined with pericardial devascularization successfully. One patient was transffered to handassisted laparoscopic splenectomy combined with pericardial devascularization due to uncontrollable hemorrhage. One patient received laparoscopic cholecystectomy firstly with volume of blood loss of about 1 500 mL and terminated surgery after infusion of suspension red blood cells of 6 U and plasma of 900 mL, and underwent laparoscopic splenectomy combined with pericardial devascularization again next week. No postoperative hemorrhage, pancreatic leakage or death occurred during the perioperative period. The operation time,volume of intraoperative blood loss, time of postoperative enteral recovery, time of postoperative drainage tube removal and duration of postoperative hospital stay were (146±33)minutes, (214±31)mL, (24±4)hours, 7 days and (14±6)days, respectively. Nine patients had postoperative pleural effusion and recovered after thoracic drainage and thoracentesis. (2) Followup situation: All the 64 patients were followed up for an average time of 19.7 months (range, 3.0-23.0 months). Reexamination of gastroscopy showed improvement of varicosed veins of lower esophagus and fundus of stomach. During the postoperative 3 months, 4 patients had portal vein thrombosis with level of PLT>700×109/L. For patients with DDimer>5, low molecular weight heparin of 0.4 U was injected subcutaneously until DDimer<2. Three patients were loss to followup at postoperative month 6 without upper gastrointestinal hemorrhage, hepatic encephalopathy or liver failure.
Conclusion:Laparoscopic splenectomy combined with pericardial devascularization is safe and effective for portal hypertension, and rigorous perioperative management offers guarantee for surgical safety.