Abstract: As for the surgeons, surgical treatment of pancreatic cancer promises to be very challenging. The concept of borderline resectable pancreatic cancer has further improved diagnostic and treatment systems of pancreatic cancer recently, but there is no verdict on the controversial problems of borderline resectable pancreatic cancer, such as the significance and indications combined with vascular resection, feasibility combined with artery resection and effect of neoadjuvant treatment. This article will go into in-depth discussions concerning the hot issues of borderline resectable pancreatic cancer in order to further improve the standardized diagnosis and surgical treatment for pancreatic cancer.