Abstract: The associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) procedure is a new surgical strategy. ALPPS is mainly used in the patients with insufficient future liver remnant (FLR) and advanced liver tumor. ALPPS provides fast and effective growth of FLR, so as to meet the normal liver function after surgery. The preliminary studies of liver regeneration of ALPPS rat model also have obtained certain achievements, a synergistic activation of the liver regeneration associated signaling pathways, such as cytokines and transcription factors, contribute to the significant liver regeneration after ALPPS. In this paper, the advantages of ALPPS and preliminary research progress are summarized.