Abstract: Staging of hepatocellular carcinoma (HCC) need to consider tumor factors and functional status of liver, which is different from other solid tumors. Now there are many clinical staging and prognosis systems of HCC. Intermediate stage HCC is commonly occurred at disease diagnosis, withvaried clinicopathological charactertics, therapeutic options and survival outcomes of patients. In this review, the definition, current therapeutic strategies, substaging model of intermediate stage HCC and the efficacy of liver resection for patients of intermediate-stage HCC are discussed for further improving feasibility of individualized surgical therapy.