Abstract: Objective:To investigate the clinicopathologic features and prognostic analysis of intrahepatic mucinous cholangiocarcinoma (IMCC) and intrahepatic cholangiocarcinoma (ICC). Methods:The retrospective cohort study was adopted. The clinicopathological data of 20 patients with IMCC and 51 patients with ICC who were admitted to the Fujian Provincial Hospital from March 2003 to March 2014 were collected. The observation indicators included (1) clinicopathologic features: gender, age, clinical symptoms (fever, jaundice, abdominal pain and peritoneal effusion), preoperative laboratory examination ［alanine transaminase (ALT), aspartate transaminase (AST), direct bilirubin (DBil), carcinoembryonic antigen (CEA), CA19-9 and alphafetoprotein (AFP)］, operation methods (radical resection, palliative resection) and pathological features (tumor location, lymph node metastasis, vascular invasion and pathological stage). (2) The followup of outpatient examination and telephone interview was performed to detect the survival of patients up to March 2015. Measurement data with normal distribution were represented as ±s and comparison between groups was analyzed using t test. Count data were analyzed using the chisquare test. The survival curve was drawn by KaplanMeier method, and the survival rate was analyzed using the Logrank test.
ResultThe numbers of patients with fever,jaundice, elevated level of AST and DBil, lymph node metastasis, vascular invasion and numbers of patients with stage 0, Ⅰ, Ⅱ, Ⅲ, Ⅳ were 13, 11, 10, 11, 3, 1 and 4, 6, 2, 6, 2 with IMCC, 12, 10, 9, 2, 22, 36 and 0, 14, 5, 3, 29 with ICC, respectively, showing statistically significant differences in the above indicators (χ²=10.830, 8.639, 7.672, 25.059, 8.036, 24.765, 26.601, P<0.05). All the patients were followed up for a median time of 14 months (range, 1-118 months). The survival time and 1, 3, 5year survival rates were (55±8)months, 94.4%, 44.0%, 16.7% in 20 patients with IMCC and (30±6)months, 36.5%, 12.5%, 4.0% in 51 patients with ICC, respectively, showing a statistically significant difference (χ²=8.126, P<0.05). Conclusion:The patients with MICC are more easily complicated with fever, jaundice and liver dysfunction, while they have less lymph node metastasis and vascular invasion, earlier pathological stage and better prognosis compared with patients with ICC.