Abstract: The incidence of adenocarcinoma of esophagogastric junction is increasing worldwide during recent decades. The therapeutic strategies have been transformed from surgery alone to multimodal treatments involing also perioperative chemoradiotherapy. Although there are still many problems on pre operative staging, surgical approach, excisional extent and perioperative chemoradiotherapy regimen, multidisciplinary team collaboration can provide an optimal diagnosis and treatment to achieve the principles of standardization and individualization in malignant tumor, which will prolong the survival and improve the quality of life for every patient.