直肠癌肝转移的分子生物学及临床实践进展
Advances in molecular biology and clinical practice of rectal liver metastases
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摘要:
结直肠癌是常见的恶性肿瘤之一，肝转移是导致结直肠癌患者高病死率的主要原因。由于解剖学特点，直肠癌在转移模式、治疗方法均不同于结肠癌。近年来基于直肠癌分子学水平的分型逐渐替代临床和病理学分期，成为预测治疗反应和预后的依据。笔者主要阐述了直肠癌肝转移的临床特点，相关分子检测及意义，手术和辅助治疗相关的进展。
Abstract:Colorectal cancer (CRC) is one of the most common malignancies, and liver metastases become the leading cause of high mortality of CRC patients. Difference in the anatomy between the colon and rectum resulting in different metastatic pattern and treatment methods between the colonic cancer and the rectal cancer. Recently, molecularbased subtyping is becoming the basis of prediction of tumor response and outcomes, replacing clinical and pathological stagings. In this review, clinical characteristics, advances of molecular detection, surgery and adjuvant therapy of rectal liver metastases are summarized.
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Keywords:
- Rectal neoplasms /
- Liver metastases /
- Molecular biology /
- Resectability /
- Individualized treatment
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