中国腹腔镜胃癌外科临床研究现状

Current status of clinical research for laparoscopic gastrectomy of gastric cancer in China

  • 摘要: 中国每年胃癌的新发病例约占全世界的42%,成为中国癌症死亡的第3大原因。由于缺乏大规模的高危人群筛查计划,>80%的中国胃癌患者确诊时已处于进展期。10余年来,和日本、韩国等国家一样,腹腔镜胃癌根治术在中国得到广泛开展。然而,由于尚缺乏高级别的循证医学证据评价这一微创技术的安全性与有效性,在应用于以根治为目的的进展期胃癌手术治疗方面仍存在争议。科学、严谨的随机对照试验被认为是提供确凿证据的最好方法。作为一个胃癌高发国家,中国理应担当更多研究责任。在日本、韩国等学术团体的帮助下,在中华医学会外科学分会腹腔镜与内镜学组、中国抗癌协会胃癌专业委员会等国内学术组织的指导下,中国胃肠微创外科专家成立了“中国腹腔镜胃肠外科研究组(CLASS研究组)”,立志于在临床循证医学研究中提供更多、更高水准的中国数据。笔者总结了中国腹腔镜胃癌外科临床研究现状,包括已经发表和正在进行的注册随机对照试验和非随机对照试验。

     

    Abstract: Gastric cancer is ranked the third cause of cancer deaths in China, and gastric cancer patients from China accounts for 42% of new gastric cancer cases worldwide. Yet, more than 80% of diagnosed gastric cancer patients were in the advanced stage partially because of a lack of national screening strategy in China. Laparoscopic gastrectomy of gastric cancer has been becoming popular in the past decades, as with Japan and Korea. Since the safety and efficacy of laparoscopic gastrectomy have not been evaluated by evidencebased medicine, laparoscopic gastrectomy in the treatment of gastric cancer in the advanced stage remains controversial, and scientific and regorous randomized controlled trial is known as the best way providing conclusive evidence. In this context, China has more responsibility for contribution to gastric cancer research. To fill this gap, the Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) group was established to offer more highquality  Chinese data in the evidensebased medicine with the great help of international academic societies like Korean Gastric Cancer Association, Japanese Gastric Cancer Association, Laparoscopic and Endoscopy Group of Surgery Branch of Chinese Medical Association and Gastric Cancer Association of Chinese AntiCancer Association. In this review, the current status of clinical research for laparoscopic surgery of gastric cancer in China was summarized.

     

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