Abstract: With the developments of digital medicine, GdEOBDTPA enhanced magnetic resonance imaging, molecular imaging and optical-/acoustic multimodality imaging, the hepatopancreatobiliary surgery have entered the era of precise diagnosis and treatment. Bidimensional pattern of disease diagnosis and treatment is developing toward threedimensional pattern, which make the diagnosis and treatment more comprehensive and clear. Morphological imaging is gradually developing towards molecular imaging. Ultimately, the goal of truly precise diagnosis and accurate treatment will be achieved.