Abstract: Pancreatic cancer is a highly malignant tumor, the incidence is increasing year by year globally. Due to concealed pathogenesis of which and rapid progress, only 25% of the patients could receive operation. Adjuvant therapy has become the important methods of improving the prognosis of patients with pancreatic cancer, including chemotherapy and radiotherapy. In recent years, some prospective clinical trials have promoted the development of the adjuvant therapy. New controversy and consensus appear in the treatment of pancreatic cancer. This article reviewed the progress of chemotherapy and radiotherapy for pancreatic cancer based on adjuvant therapy and neoadjuvant therapy for unresectable metastatic pancreatic cancer and locally advanced pancreatic cancer.