Abstract: Pancreatic carcinoma is a high malignancy, as radical resection is the only cure for longterm survival. In an attempt to improve outcomes and prognosis, surgeons over the decades have employed various active surgical strategies to combat this disease. Through document analyses of radical pancreaticoduodenectomy for pancreatic head carcinoma, regional lymphadenectomy, retroperitoneal nerve dissection, and combined vessel resection, the extent and disputes about radical resection for pancreatic head carcinoma are investigated. Total mesopancreas excision appears to be a novel and promising surgical procedure for the improvement of prognosis of patients with pancreatic head carcinoma. However, further studies based on the data of larger number of patients are mandatory to raise the evidence for this surgical procedure.