巴塞罗那临床肝癌B期和C期患者施行部分肝切除术治疗的国际争议

International controversy in partial hepatectomy for patients in stage B or C of Barcelona Clinic Liver Cancer

  • 摘要: 巴塞罗那临床肝癌(BCLC)分期已被欧洲肝病研究协会(EASL)和美国肝病研究协会(AASLD)推荐为肝细胞癌的最佳分期和治疗指南。该指南认为:肝切除术只适用于BCLC 0期或A期患者,而不适用于BCLC B期和 C期患者。近年来多项回顾性研究结果显示:BCLC B期和C期患者接受部分肝切除术后的长期生存率高于仅接受TACE和全身治疗患者,引起国际上肝癌研究者的激烈争议。因此,是否将部分肝切除术作为BCLC B期和C期患者的治疗方法有待进一步研究和决定。

     

    Abstract: Barcelona Clinic Liver Cancer (BCLC) has been recommended as the best staging system and treatment guideline for hepatocellular carcinoma by European Association for the Study of the Liver (EASL) and the American Association for the Study of the Liver Disease (AASLD), assuming that hepatectomy is only for patients in stage 0 or A of BCLC rather than for patients in stage B or C. Recent retrospective studies show that the longterm survival rate of patients in stage B or C receiving partial hepatectomy is higher than Transhepatic Arterial Chemotherapy and Embolization (TACE) and systemic treatment, leading to controversies among international scholars. Therefore, whether or not partial hepatectomy as the treatment method for patients in stage 0 or A of BCLC need further researches to determine.

     

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