Abstract: Pancreatic tuberculosis(PTB) is a rare, chronic, specific and infectious disease which is generally secondary to tuberculosis at the common sites of pancreas, and it has a high misdiagnosis rate due to the hidden onset and nonspecific symptoms of PTB. A patient with PTB was admitted to the First Affiliated Hospital of Zhengzhou University in June 2014. Before operation, the spaceoccupying lesions of the head of pancreas were detected by preoperative imaging examination, and the patient was regarded as with pancreatic cancer. Intraoperative exploration showed cystic duct involvement, and the granulomatous inflammation was detected by rapid pathological examination using frozen section technique, after that the patient received granuloma resection+cholecystectomy according to suspected PTB. The diagnosis of PTB was confirmed by postoperative pathological examination, and the patient received liverprotective and antituberculosis treatments after discharge.